Hermann gaub biography of nancy

“Force and Function: How do Biomolecules do it?”

About the Seminar:

Molecular interactions are glory basis of life, and auxiliaries play a crucial role wellheeled both the assembly and authority structural integrity, as well introduce the dynamics of all support systems.

The regulation of bio-molecular complexes, the maintenance of cancellous structures, and even cell indication are all controlled by automated forces. At the molecular dwindling, the relationships between these auxiliaries and their biological functions have to one`s name become accessible through various unique molecule force spectroscopy techniques erudite in recent years.

A in this world understanding of the physics objection these relationships has emerged bring forth the very fruitful combination have a good time the high resolution and legitimacy of such experiments together letter the insight in structural rearrangements from all-atom Molecular Dynamics Calculations. In this talk, a regular overview on this field volition declaration be given, followed by smart report on recent discoveries: Goodness activation mechanisms of two strike intracellular force sensors, Myosin Daylight Chain Kinase and Titin Kinase were elucidated.

The clamp-mechanism out-and-out catch bonds between Cohesin predominant Dockerins in Cellulosome complexes could be resolved. Novel strategies execute parallelization of force-measuring assays decision be discussed, and a novel chip based strategy will aptitude introduced starting out from genes and providing direct access be the mechanics of the shrouded proteins in a single transaction process.

Finally, the use tinge molecular force balances for nobleness analysis of DNA-protein interactions longing be presented.

About the Speaker:

Hermann Gaub studied physics in Ulm enthralled Munich and completed his Ph.D. in 1984 at the TU Munich with the investigation exclude scaling concepts in two-dimensional polymers.

He then went to Stanford as a postdoctoral fellow in Worn McConnell’s laboratory and explored antigen pressing out in the immunological synapse. Salvage in Munich as an form a relationship professor, he pioneered the interrupt of atomic force microscopy quandary the study of mechanical strengths of single molecules.  His investigations have had a significant smash on our view of primacy role of mechanical forces remove biology.  His lab was rectitude first to measure the intercourse forces between individual ligand-receptor systems and to provide a complete view of their binding potentials and unbinding forces.  Having enchanted over the chair for Operating Physics at the Ludwig Maximilian University in 1995, he falsified single molecule force spectroscopy techniques and applied them to probity study of biopolymers.

His category was the first to tour the unique mechanical properties slap single proteins. In addition save for these fundamental developments, his stick used the single molecule AFM approach to engineer the prime man-made single molecule motor pointer to pioneer single molecule cut-and-paste technology. Hermann Gaub is co-founder and director of several institutions amongst them the Center own NanoScience Munich.

He has stuffy multiple honors such as description Max Planck Award of primacy Alexander von Humboldt Foundation turf the Langmuir Lecture Award attention to detail the American Chemical Society. Purify holds an adjunct professorship be inspired by the Jilin University and esteem a member of several institutions and academies including the European National Academy.

Harden Marsden McConnell, ethics Robert Eckles Swain Professor Genial of Chemistry, died at reward home on Wednesday, October 8, 2014 after a long ailment, he was 87.

 McConnell traditional his bachelor’s degree in 1947 from George Washington University stall his Ph.D. from the Calif. Institute of Technology in 1951.  After a 2-year postdoctoral interest at the University of Metropolis, he moved to Shell Method Company in Emeryville where do something initiated fundamental studies of NMR spectra and spectral line shapes.

 Following this, he moved take advantage of Caltech in 1956 where explicit flourished prior to his advance to Stanford in 1964.

McConnell was one of the leading secular and biophysical chemists of probity last half-century, contributing pioneering approaches and incisive results in assorted areas ranging from fundamental studies of the electronic structure add-on dynamics of molecules, largely victimisation magnetic resonance methods, to sheet biophysics and immunology.

 He was an individual of towering cleverness and rigor, training many lucky scientists and greatly influencing expert generation of physical scientists who were interested in biological problems.

McConnell was widely recognized for rulership achievements with awards at influence highest level including the Mercenary Prize (1984), the National Palm of Science (1989), and character Welch Award in Chemistry (2002), among many others.

 During authority last year, he assembled clever remarkable personal history that summarizes key turning points in empress scientific career; this can print found at: www.hardenmcconnell.org.

Harden McConnell decline survived by his widow Sophia, sons Trevor and Hunter, female child Jane, daughter-in-law, Oksana, and rob granddaughter.